McGuire will make the announcement at 6 p.m. during the grand opening of his campaign headquarters at 4158 Washington Road, Suite 10, Evans.
An Appling resident, McGuire is the former plant manager of Sweetheart Cup Co. of Augusta. He also once served as board chairman of the Columbia County Chamber of Commerce.
Previously, he made two failed attempts to win seats in the state Legislature.
McGuire will take on commission Chairman Ron Cross, who announced his intention to seek a third term of office in November.