Obama called Cooper an example of "the heartbreak and the hope," noting that she had lived long enough to remember when black people weren't able to vote and was able to vote for the country's first black president.
Cooper's grandson Albert Cooper told The Atlanta Journal-Constitution that his grandmother died this afternoon.
Atlanta City Councilman Ivory Young said he met her when running for office in 2001 and found her stories about Atlanta history mesmerizing.
Former Atlanta Mayor Andrew Young recounted Cooper's legendary vibrancy, noting that she had taught senior citizens aerobics until she was 100.
He danced at Cooper's 104th birthday party, chuckling at the memory of how she outperformed him.
He said she would have turned 108 on Jan. 9.