The Lexington County Sheriff's Department says the accident happened on Interstate 77 near Cayce shortly before 4 a.m. today.
Department spokesman Capt. John Allard says warrants charging 38-year-old Frank E. Milton Jr. of Columbia would be served once he is out of the hospital.
Sheriff James R. Metts said Milton's SUV hit a South Carolina Highway Patrol cruiser, which forced a disabled Honda station wagon into a tow truck. He said 36-year-old Kevin Butler of West Columbia was preparing to load the station wagon when he was struck. Butler died at the scene.
The driver of the station wagon, 48-year-old Walter Moultrie III of Hanahan, was listed in serious condition tonight.
Allard didn't know if Milton had an attorney.