Effingham County Sheriff's spokesman David Ehsanipoor said Georgia State Patrol troopers and sheriff's deputies began following a vehicle with two people in it in Chatham County late Saturday night.
The chase extended into Effingham County, where deputies used spike strips to flatten the car's tires. The car lost control, hitting another vehicle.
Both suspects died in the wreck. Police have not released their names.
Police say the suspects also hit two other vehicles during the chase, injuring two people. Their names and conditions were not immediately available.