Bryant padded his lead today with a 5-under 67 to put him at 15-under after three rounds at Crosswater Golf Club in central Oregon.
Augusta native Larry Mize shot 70 and is fourth, five back. Former Augusta resident Allen Doyle shot 68 and is tied for 11th, nine back.
Reid birdied the par-4 No. 18 to finish with a 66 and go to 13 under in the fourth of five majors on the Champions Tour.
Bryant extended his lead with back-to-back birdies on the 15th and 16th holes. He came close to another one on the par-3 No. 17, but his putt came to rest just on the lip of the hole.
Bryant has stayed atop the leaderboard after shooting a career-best 10-under 62 in the opening round, matching a tournament record.