The 50-year-old Jackson real estate developer shot 5-under 67 at Crooked Stick to take the lead at 11-under 133 matching the lowest 36-hole total in event history. He opened with 66 on Thursday, the best score ever by an amateur in the tournament.
Norman stumbled early in the round, but recovered nicely, ending the round with two consecutive birdies to get to 8-under. He was three strokes back after 70.
Sindelar was a stroke behind Jackson. He started on the back nine and followed his course-record 66 with 68. A birdie on No. 6 gave Sindelar a share of the lead, but he dropped a stroke on the next hole and finished the day by pulling a 5-foot birdie putt that would have tied Jackson to the left.
Fred Funk (67) was third at 9-under.
Augusta native Larry Mize shot his second consecutive 73 and was 2-over.
Former Augusta resident Allen Doyle shot 78 to finish at 148 and missed the cut. Augusta native Jim Dent, who opened with 76, withdrew.