Multiple media outlets report that Redfearn Health Center executive director George Clay says the student reported mild flu-like symptoms on June 22.
Clay says the student lives off-campus, was treated with Tamiflu and has fully recovered.
Clay says it's "highly likely" more cases will be reported.
The state Department of Health and Environmental Control has confirmed 120 cases of swine flu statewide. No one in South Carolina has died as a result of the illness.
The Centers for Disease Control and Prevention says more than 27,000 confirmed and probable cases have been reported nationwide, resulting in 127 deaths.