Schlopy became only the fourth player in World Series history to homer twice in one game, and the sixth-seeded Bulldogs set a Series record with four home runs in a game.
Schlopy's three-run blast into the stands in left field put Georgia (46-11) on top 5-3 in the second inning, and Ashley Pauly and Brianna Hesson also homered.
Christie Hamilton (26-9) came on in relief and picked up her second win of the day despite having a series of illegal pitches called against her.
Roya St. Clair homered and drove in three runs to lead the Michigan (47-12) offense.
Earlier Saturday, Kristyn Sandberg hit a two-run home run and Kristin Schnake added a two-run double as Georgia beat Missouri 5-2.
Missouri became the first team eliminated from the eight-team event.
Sandberg gave the sixth-seeded Bulldogs a 3-0 lead in the fourth inning when she hit her eighth home run of the season with a line drive to center field. Schnake made it 5-0 an inning later as Georgia cashed in after Chelsea Thomas (16-7) issued a walk, hit a batter and threw a wild pitch.
Georgia starter Christie Hamilton (25-9) gave up only a two-run single to Marla Schweisberger after a disputed call kept a rally going in the sixth inning for the Tigers (50-12).