The Earthquake Hazards Program of the U.S. Geological Survey said the 2.5 magnitude temblor was recorded near Summerville just after 1 p.m. Wednesday.
The epicenter was near a fault blamed for a deadly magnitude 7.3 earthquake in 1886 that killed more than 100.
In December a 3.6 magnitude quake tipped over Christmas trees, knocked pictures off walls and caused minor injuries.
Erin Beutel, a College of Charleston geologist, said quakes have been recorded this year near Columbia, between Orangeburg and Aiken, and north of Florence. None caused damage.