Ty Lawson scored 19 points and Danny Green added 18 to lead the top-seeded Tar Heels to a 72-60 win over Griffin and Oklahoma on Sunday in the South Regional final.
North Carolina (32-4) advanced to the Final Four for the second straight year and will play Villanova in the national semifinals.
Griffin scored 23 points with 16 rebounds for Oklahoma, but the Sooners (30-6) went 2-for-19 from 3-point range.
North Carolina advanced to a record 18th Final Four. UCLA has been to 18, but the Bruins' 1980 appearance was later vacated by the NCAA because of rules violations.
This will be the Tar Heels' ninth Final Four in 19 seasons - and it will be played at Detroit's Ford Field, where they routed Michigan State 98-63 in December. Earlier Sunday, the Spartans also reached the Final Four.