Tuesday's state Capitol news conference was the first stop in a statewide tour for Isakson, an Atlanta real estate developer.
No Democratic challenger has emerged yet to challenge Isakson.
Instead, all eyes have been on the open governor's seat that will be up that same year.
Isakson recently voted against the federal stimulus package President Barack Obama is set to sign into law.
But he acknowledged on Tuesday that it will mean "significant money coming to Georgia" for programs such as cash-strapped programs like Medicaid and transportation.