After Hoffman missed a birdie putt on No. 17, Perry sank his birdie attempt for the win. Hoffman missed birdie putts on Nos. 17 and 18 in regulation before Perrys bogey forced the playoff.
Perry, the leader after 54 holes, and Hoffman finished at 14-under 270 at TPC Scottsdale. Perry shot 69 in the final round. Hoffman had 67.
Perry had three victories on the PGA Tour in 2008. He won the Memorial, the Buick Open and the John Deere Classic.
Former Louisville, Ga., resident Brian Gay, who shot 70 in the final round, tied for sixth with three others at 11-under. Evans Vaughn Taylor shot 72, finishing at 1-under and tied for 53rd.