Justin Leonard and Ryder Cup rookie Hunter Mahan won both their matches. Phil Mickelson teamed with another rookie, Anthony Kim, to halve a morning match and win a full point in the afternoon.
Ian Poulter and Justin Rose provided the only win for the Europeans, beating Steve Stricker and Ben Curtis 4 and 2. Otherwise, the day belonged to the Americans, who had four outright wins and halved three other matches.
The United States has its largest Friday lead since 1979, the first year all Europeans were allowed to compete. Before that, the Americans faced a team from Great Britain and Ireland.