Peyton Manning threw for 308 yards and four touchdowns, including a 65-yarder to Reggie Wayne to go ahead for good, and the Colts beat the Jacksonville Jaguars 35-31 on Thursday night to improve to 14-0 for the first time in franchise history.
"Reggie just used his speed," Manning said. "What a great job once he caught the ball to get into the end zone."
The wild game on a cool night included 714 yards, 43 first downs, 10 lead changes, five punts, several big plays and only two turnovers.
"I thought today was a great test against a good team," Manning said. "Feel real good about the win."
The Jaguars (7-7) had a chance to win it in the closing minutes, but David Garrard overthrew Mike Thomas on a third-and-10 play with about a minute to play. Jacob Lacey intercepted the ball, and the Colts ran out the clock.
Indianapolis extended its NFL-record winning streak in the regular season to 23 and became the third 14-0 team in league history, joining the 1972 Miami Dolphins and 2007 New England Patriots. New Orleans can join the list with a victory over the Dallas Cowboys on Saturday night.
Jacksonville lost for the third time in the four games and no longer controls its fate in the AFC wild-card race. The Jaguars, who have lost eight of 10 in the series, got in a shootout with Manning & Co., which turned out to be a huge mistake.
Garrard was 23 of 40 for 223 yards with three touchdowns. Maurice Jones-Drew ran 27 times for 110 yards and a score. But once the Jaguars got behind and abandoned the running game, they had trouble sustaining drives.