CLEMSON, S.C. --- C.J. Spiller had a career-high 165 yards rushing and his 20th touchdown of at least 50 yards and Clemson took its biggest step yet toward an Atlantic Coast Conference title with a 40-24 victory over Florida State on Saturday night.

Spiller, the Tigers' star senior, caught a 58-yard TD pass from Kyle Parker and, with 312 all-purpose yards, surpassed the school record of 310 he set in Clemson's 40-37 overtime win at Miami two weeks ago.

He also closed Clemson's fifth victory over the Seminoles (4-5, 2-4) in the past seven meetings with a high-stepping, 5-yard scoring run as the orange-clad fans shook Death Valley.

Spiller and the Tigers (6-3, 4-2) are now in control of the ACC's Atlantic Division with games against North Carolina State and Virginia left.

Clemson's defense pitched in, too, intercepting ACC passing leader Christian Ponder four times.

Florida State coach Bobby Bowden, who turns 80 today, and his team is in danger of missing out on a bowl bid. Those who have wondered if it was time for Bowden to step aside will likely start to grumble again, too.

A two-game winning streak muted the critics and put Florida State back in the Atlantic Division race. Those hopes are gone now after the first Clemson-Florida State game that did not match Bowden against his son, Tommy, in years.

Fans rushed Frank Howard Field with a sense Clemson was closing in on a championship goal.

The Seminoles had hoped to get a rousing effort from a defense that had struggled all year after longtime coordinator Mickey Andrews announced he was leaving after the season.

Instead, Spiller ran through the Seminoles for a record performance.

He'd earlier become the school's all-time pass catcher among running backs and he and track partner, receiver Jacoby Ford, broke an NCAA mark for all-purpose yardage by teammates, bettering the 10,253 yards of Marshall Faulk and Darnay Scott of San Diego State.