The top five teams earned berths in the National Champion-ships, scheduled for May 26-30 in Toledo, Ohio.
The Jaguars, who began the day 12th, shot 5-under 279, their low round of the tournament by three shots, to finish at 2-over 854.
Central Florida shot 11-under 273 to finish at 34-under 818 and win the regional by 11 shots over South Carolina, Georgia and Arizona. The Gamecocks shot 15-under 269, the low round of the tournament, Georgia shot 272 and Arizona shot 282.
Iowa also qualified for the national championships by shooting 276 to finish fifth at 837, six shots ahead of Georgia State, which shot 281.
Georgia Southern shot 275 and finished 10th at 847.
Arizona's Tarquin MacManus claimed medalist honors, shooting 2-under 69 in the final round to finish at 15-under 198, two strokes better than Central Florida's Brad Schneider.
Henrik Norlander shot 71 to tie for 23rd at 210 and lead Augusta State. Freshman Taylor Floyd had 67 and tied for 27th.
In the Central Regional in Alvaton, Ky., Georgia Tech closed with 7-over 295 to finish third and advance to the NCAA Championship.
Clemson did not advance from the Northeast Regional. The Tigers had a final-round of 15-over 299 and finished ninth.
GEORGIA MID-AM: Augusta's Jeff Knox fired his second consecutive 5-under-par 67 and carries a five-shot lead into today's final round of the Georgia State Golf Association event at White Columns Country Club in Alpharetta, Ga.
"White Columns seems to set up nice to the way I like to play," Knox said.
Knox, who is at 10-under for 36 holes, can become the third player to win back-to-back Mid-Amateur titles.
Sharing second place are Adam Cooper (70 on Saturday), of Columbus; Dave Poeteet (67), of Duluth; Mark Strickland (70), of Woodstock; and Winston Morris, (72) of Marietta.
Counting Knox, four of the five area players made the cut.
Alpharetta's Doug Weiss, a former Augustan has shot 71-72--143 at his home course and is tied for 12th place, nine shots behind Knox. Brad Jones (73-72) and Ralph Ireland III (72-73) are tied for 24th place at 145.
Former Mid-Amateur champion Jefferson Murray, of Augusta, shot 76-75--151 and missed the cut by a shot.