Bryant, who birdied nine holes in the opening round, set the pace early by birdieing six of his first 10 holes and capped his round with a 10-foot birdie putt on 18 for a 15-under 129 total.
Jay Haas, the 2007 player of the year, was third at 13-under after shooting 66.
Hale Irwin, at 63 trying to become the oldest winner in the tour's 30-year history, had 67 to join Jeff Sluman at 12-under, a stroke ahead of Andy Bean (66).
Bryant is seeking his first victory since the 2007 U.S. Senior Open, where he made up five strokes in the final round and overtook Tom Watson in the second-largest comeback in Open history. Bryant will be the hunted today.
Langer made his move on the back nine, making birdies on four of the final six holes for 66.
EUROPEAN TOUR: In Doha, Qatar, Alvaro Quiros, of Spain, had eight birdies for 8-under-par 64 to lead Louis Oosthuizen by one stroke after the third round of the Qatar Masters.
Quiros, who made five birdies on the front nine, totaled 16-under 200 at Doha Golf Course.
"I have been telling people that I am not just a long hitter," Quiros said. "It has been a lucky week for me. I could see this score coming. I can't even remember when was the last time I won."
Oosthuizen, of South Africa, who led by three strokes after 36 holes, had 69. Maarten Lafeber, of the Netherlands (66), and Henrik Stenson, of Sweden (66), are four strokes behind the leader.
Andrew Coltart, of Scotland (70), was five shots off the pace, while Spanish pair Sergio Garcia (67) and Miguel Angel Jimenez (70) were in a group that was six shots behind.
Former Augusta State golfer Gary Murphy had 73 is at 215, 15 shots off the lead. Fellow former Jaguar Oliver Wilson shot 74 and is at 216.
LPGA: In Rio DeJaneiro, Brazil, Catriona Matthew, the 39-year-old Scot five months pregnant with her second child, shot 3-under-par 69 to take a two-stroke lead after the first round of the HSBC LPGA Brazil Cup exhibition tournament.
"I'm feeling fine actually," Matthew said. "I get a little tired toward the end, but it's not really affecting me just yet."
Kristy McPherson had 71, and Brazil's Angela Park opened the 36-hole, 15-player event with 72.
COMPTON GETS SPOT: Former University of Georgia golfer Erik Compton, who underwent a second heart transplant last year, received a sponsor exemption into the Honda Classic.
It will be the second PGA Tour event for Compton since getting his third heart last May. Compton made the cut at the Children's Miracle Network Classic at Disney in November, finishing 60th.
The Honda Classic starts March 5 at PGA National in Palm Beach Gardens, Fla.