The Blue Devils (14-1, 2-0 Atlantic Coast Conference) ran off the first nine points of the second half during a 41-11 run to build their largest lead of the game, 46-21 with 12:45 left.
Toney Douglas led Florida State (13-3, 0-1) with 18 points, but was just 7 of 23 from the floor.
NO. 5 CONNECTICUT 81,
In Cincinnati, A.J. Price made five of eight 3-pointers and scored 22 points, and the Huskies remained unbeaten on the road.
The Huskies (14-1, 3-1 Big East) improved to 7-0 on the road while shooting 58 percent from the field. Jeff Adrien added 13 points and 12 rebounds and Jerome Dyson had 12 points.
Deonta Vaughn scored 19 points, Mike Williams 14 and Yancy Gates 12 for Cincinnati (10-6, 0-3), which has lost four in a row.
NO. 6 OKLAHOMA 61,
KANSAS STATE 53
In Manhattan, Kan., Blake Griffin had 29 points and 15 rebounds in a rare game against single coverage, helping Oklahoma open Big 12 Conference play with a win.
Oklahoma (15-1) was 9-7 and won just three road games in the Big 12 last season.
Denis Clemente led Kansas State (11-4) with 18 points and Fred Brown added 12.
NO. 7 TEXAS 75, IOWA STATE 67
In Austin, Texas, Damion James scored 19 points to lead Texas in the Big 12 opener for both teams.
Gary Johnson added 17 points and nine rebounds for the Long-horns (12-3), who are undefeated in 11 conference home openers under coach Rick Barnes.
Craig Brackins scored 20 and grabbed 13 rebounds to lead Iowa State (11-5).
NO. 8 MICHIGAN STATE 75,
In East Lansing, Mich, Michi-gan State overcame a shaky start and lackluster stretch in the second half against the defending national champions.
Kalin Lucas continued his offensive surge, scoring 22 points to lead the Spartans (13-2), who have won nine in a row since getting routed by North Carolina.
Sherron Collins and Cole Aldrich, the only current players who had an impact on last season's national championship team, scored 25 and 14 points respectively for Kansas (11-4).
NO. 9 GEORGETOWN 82,
In Washington, Austin Free-man scored 18 points, Greg Mon-roe nearly had a triple-double, and Georgetown held Providence scoreless for more than 6 minutes to rally and snap a two-game Big East losing streak.
Georgetown (11-3, 2-2) trailed by nine points in the first half, and allowed Providence (11-5, 3-1) to go ahead 44-40 on Brian McKenzie's 3-pointer with 16:15 left.
That, though, is when Monroe began to get more assertive, leading a 15-0 run by the hosts. After a one-basket first half, he finished with 13 points, 11 rebounds and eight assists.
NO. 13 NOTRE DAME 88,
SETON HALL 79
In South Bend, Ind., Luke Harangody scored 30 points to lead Notre Dame as the Irish tied a Big East record with their 20th consecutive league win at home.
The Irish (12-3, 3-1 Big East) have won 45 in a row overall at home. The Pirates (9-7, 0-4) have lost four in a row.
NO. 17 BOSTON COLLEGE 71
In Boston, Dwayne Collins had 13 points and seven rebounds and drew a key charging foul on Tyrese Rice in the final minute to lead Miami (12-3, 1-1 Atlantic Coast Conference).
It was the second consecutive loss for the Eagles (13-4, 1-1 ACC) since they beat top-ranked North Carolina in Chapel Hill to jump into The Associated Press Top 25.
Rice had 21 points for Boston College.
NO. 23 LOUISVILLE 61,
NO. 18 VILLANOVA 60
In Philadelphia, Terrence Williams scored on a drive with 7.4 seconds left to give Louisville the lead, and Villanova missed two shots down low in the final seconds.
Earl Clark had 16 points and 11 rebounds for Louisville (11-3, 2-0 Big East), which won its third in a row after losing two of three.
Dante Cunningham had 21 points for Villanova (13-3, 1-2), which only led twice in the game.
NO. 18 MARQUETTE 75,
NO. 25 WEST VIRGINIA 53
In Milwaukee, Jerel McNeal had 26 points to lead Marquette.
Dominic James added 17 and Wesley Matthews scored all 13 of his points in the second half for the Golden Eagles (15-2, 4-0 Big East).
Da'Sean Butler led West Vir-ginia (11-4, 1-2) with 16 points.
NO. 20 ARIZONA STATE 76,
In Tempe, Ariz., Derek Glasser scored 15 points and had a career-high 11 assists, and Arizona State won for the 10th time in 11 games.
James Harden scored 19 points for the Sun Devils (14-2, 3-1 Pac-10).
NO. 21 BUTLER 54, DETROIT 50
In Indianapolis, Matt Howard scored 11 of his 15 points in the second half, including two free throws with 0.8 seconds left to help Butler hold on.
The Bulldogs (14-1, 5-0) won their sixth in a row overall.
NO. 23 BAYLOR 73, TEXAS TECH 61
In Waco, Texas, LaceDarius Dunn scored 20 points, including 11 in a row in the second-half spurt that put Baylor ahead for good in the Big 12 opener for both teams.
Dunn's game-deciding spurt began with just over 12 minutes left when he hit a 3-pointer. After a Tech free throw tied the game at 45, Dunn hit another 3-pointer with 11:11 left and the Bears (13-2) led for good.