Flu resistance causes concern

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What might be an emerging strain of flu resistant to the anti-viral drug Tamiflu could affect plans to respond to a bigger flu pandemic, one flu expert said.

In its last national flu report for the week ending Dec. 20, the Centers for Disease Control and Prevention noted that 64 of 65 samples of the influenza A H1N1 strain were resistant to oseltamivir, marketed as Tamiflu.

Dr. James A. Wilde of Medical College of Georgia, who sits on a statewide planning committee for pandemic flu, said he was concerned but not alarmed at this early evidence, which both the CDC and Dr. Wilde noted is from a very small number of samples.

Still, it reminded Dr. Wilde of a similar antiviral resistance that cropped up suddenly in another strain of influenza A, which became resistant to the adamantane antivirals.

"This was almost overnight," Dr. Wilde said. "The year before we had very low levels and all of a sudden we skyrocketed to 90 percent (resistant)."

At the end of last year's flu season, 10.9 percent of the influenza A H1N1 strains were resistant to Tamiflu, up from .7 percent from the previous flu season, the CDC reported.

The agency noted that it is too early to draw any conclusions about how widespread resistance might be.

The concern would come in the federal government's reliance on Tamiflu to respond to a flu pandemic, when a flu strain mutates enough to cause more widespread illness and result in greater hospitalizations and deaths.

Though Tamiflu is the recommended treatment for the sick, the federal plan calls for essential personnel such as policemen and firemen to take it as protection during a pandemic.

Moreover, the federal government is now urging hospitals and even small businesses to think about stockpiling Tamiflu to protect employees.

"One of the concerns would be if the current (influenza A) H1N1 mutates and the mutated version has the same resistance gene to Tamiflu that H1N1 does right now," Dr. Wilde said. "That would be a recipe for disaster. But it's also quite possible that whatever the pandemic strain is, it will be a strain that is sensitive to Tamiflu."

The bigger concern would be if the trend continues of first one flu strain becoming resistant to the existing antivirals, followed by a different strain, he said.

"We're going in a direction that is quite ominous," Dr. Wilde said.

Reach Tom Corwin at (706) 823-3213 or tom.corwin@augustachronicle.com.

IS IT FLU YET?

Although some community physicians reported a spate of positive flu cases from rapid tests last month, Dr. James Wilde of Medical College of Georgia said he doubts flu is really in the area.

The tests, which studies have shown to be between 55 percent to 90 percent accurate, often give false positives in the absence of a widespread prevalence of flu, he said.


The Centers for Disease Control and Prevention lists both Georgia and South Carolina as having a Sporadic level of flu activity.


GEORGIA: So far, the state has had only one lab confirmed case of flu, although there are seven among soldiers at Fort Benning, according to the Georgia Division of Public Health.


SOUTH CAROLINA: The state's Department of Health and Environmental Control listed one lab-confirmed case from Charleston County as of Dec. 20.

Comments

FallingLeaves

I don't know what strain of flu I had, but don't take it lightly. I had it for over 2 weeks and it was rough, despite getting a flu shot early in the season.

soldout

Flu is a natural de-tox process for your body. If you need to have the flu you probably will get it and if you don't you won't. One doctor's testing showed a large rise in Alzheimers among those who take flu shots on a regular basis. The CDC flu death numbers are about 1700 a year ; not the 1000s reported on local TV. Once again it is about money and not health. It isn't flu season, it is actually "too much sugar and not enough sun season" when lowers your body to become very toxic.

msitua

Anytime when you take a shot or a med to prevent a certain virus, such as a flu virus, a vacuum is created and other viruses wiill appear to replace the ones that are suppressed. It's a no win situation so no wonder some strains will become resistant to tamiflu.
Maurine Meleck

msitua

Best way to prevent flu during the winter season is to take very large doses of vitamin D3(depending on your body weight) to replace that lack of sun that helps keep us well.
MM

soldout

If you do get sick NAET can be the best fix. There is an excellent NAET office in Wagener, SC. Inexpensive, fun, non-invasive, no drugs treatment that is years ahead of anything around here.

FallingLeaves

How do they know people have the flu if they don't report it? I didn't go to a doctor for it.

corgimom

"One doctor's testing showed a large rise in Alzheimers among those who take flu shots on a regular basis"- of course, that might be because it is mostly the elderly that take flu shots on a regular basis, and that's who gets Alzheimer's.

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