Chay Shegog added 12 points and 11 rebounds for the Tar Heels (6-0), who scored the game's first 14 points and limited Wofford to 20-percent shooting. Iman McFarland and Laura Broomfield also scored 12 points apiece for North Carolina.
Natalie Gramblin led Wofford (0-2) with 10 points.
Wofford, which trailed 50-14 at halftime, missed its first 15 shots from the field and committed 14 turnovers before its first basket. The Terriers shot 3-for-29 in the first half and had 20 turnovers.
NO. 9 TENNESSEE 83, WESTERN CAROLINA 56
In Knoxville, Tenn., freshman Glory John-son tied a career-high with 19 points and the Lady Vols romped.
Tennessee (4-1) rallied from a sluggish start to pull away late in the first half and give coach Pat Summitt her 987th victory in 35 seasons.
The two-time defending national champion Lady Vols trailed 19-18 midway through the first half, but outscored the Lady Catamounts 31-7 in the final nine minutes for a 49-26 halftime lead.
Tennessee sophomore Vicki Baugh added her second consecutive double-double with 11 points and a team-high 14 rebounds.
NO. 14 NOTRE DAME 85, GEORGIA SOUTHERN 36
In South Bend, Ind., Brittany Mallory scored a career-high 19 points and Notre Dame jumped on Georgia Southern early.
Notre Dame (4-0) scored 37 points off of 24 Georgia Southern turnovers and harassed the Eagles into shot clock trouble all night.
J'Lisia Ogburn, Ashley Rivens and Ashley Melson each scored eight points to lead Georgia Southern (3-2), which shot only 21.4 percent from the field.