Griffin's three-point play with 2:06 left put Oklahoma (4-0) ahead 76-74, and Austin Johnson hit three free throws in the final 20.6 seconds to help the Sooners avoid the upset.
Griffin was 14 of 20 from the field for Oklahoma, which will resume play in the NIT Season Tip-Off against Alabama-Birmingham on Wednesday in New York.
NO. 3 LOUISVILLE 79,
MOREHEAD STATE 41
In Louisville, Ky., Louisville freshman center Samardo Sam-uels scored 18 points to lead four players in double figures, and the Cardinals rolled by Morehead State in the opening round of the Billy Minardi Classic.
Earl Clark scored 13 points, Jerry Smith had 12 and Preston Knowles added 10 as the Card-inals (1-0) powered the over-matched Eagles (0-4) in the second half.
NO. 6 PITTSBURGH 86,
INDIANA (PA.) 60
In Pittsburgh, DeJuan Blair missed only one shot while scoring 27 points and getting 18 rebounds and Pittsburgh scored the first 20 points before easing to a victory over NCAA Division II opponent Indiana, Pa.
The 6-foot-7 Blair was too strong and mobile inside for the undersized Crimson Hawks (2-1) and had 20 points and 16 points as Pitt led 45-17 at halftime. Blair, who made 13 of 14 shots and his only free throw, lifted the Panthers (4-0) ahead 54-21 with 14:33 remaining after he scored three consecutive baskets.
NO. 11 PURDUE 66,
COPPIN STATE 46
In West Lafayette, Ind., Robbie Hummel had 20 points and 11 rebounds, and Purdue beat Coppin State.
It was the sixth double-double of Hummel's career, and his first this season.
Nemanja Calasan scored 11 points and E'Twaun Moore added 10 points, eight rebounds, five assists and three blocks for the Boilermakers (4-0). Purdue's next game will be against Boston College on Wednesday in the NIT Season Tip-Off semifinals at Madison Square Garden.
NO. 22 GEORGETOWN 81,
In Washington, freshman Greg Monroe had 20 points and eight rebounds to lead Georgetown.
The 6-foot-11 center from New Orleans was 7-for-9 from the field while adding four assists, three steals and three blocked shots for the Hoyas (2-0). Austin Freeman added 16 points.