Coming in with a nation-best plus-10 turnover ratio, the Demon Deacons (3-1) committed six turnovers in a dreadful performance a week after dominating Florida State.
Riley Skinner's fourth interception midway through the fourth quarter set up Bryant's 4-yard run with 3:45 left and ended Wake Forest's comeback from a 17-0 deficit.
Navy (3-2) earned its first win over a ranked team since a 17-13 win over No. 20 Virginia in 1985.
FLORIDA STATE 39, COLORADO 21
In Jacksonville, Fla., Antone Smith ran for 154 yards and three touchdowns as the Seminoles defeated previously unbeaten Colorado in Bobby Bowden's 500th game as a college head coach.
Florida State (3-1) scored three times in the final 2:29 of the first half to take a 19-7 lead on the way to its first win of the season over a Bowl Subdivision team.
Smith, who carried 25 times, went 60 yards down his own left sideline with 2:29 left in the half to give the Seminoles a 14-7 lead.
Cody Hawkins threw for 154 yards and three touchdowns for Colorado (2-1).
DUKE 31, VIRGINIA 3
In Durham, N.C., the Blue Devils took advantage of five second-half turnovers to beat Virginia and end a 25-game Atlantic Coast Conference losing streak.
Quarterback Thaddeus Lewis completed nine of his first 10 pass attempts after halftime, and Duke scored three touchdowns in a 10-minute span.
Duke's last ACC victory before Saturday was Nov. 13, 2004, a 16-13 home victory over Clemson. Virginia (1-3, 0-1) has been outscored 128-36 this season.
NORTH CAROLINA 28, MIAMI 24
In Miami, Cameron Sexton threw a 14-yard touchdown pass to Brooks Foster with 46 seconds left, Trimane Goddard had two interceptions in the final minutes, and North Carolina rallied from an early 14-point deficit.
Sexton -- playing because North Carolina starter T.J. Yates will miss six weeks with a broken left ankle -- relieved starter Mike Paulus early and completed 11 of 19 passes for 242 yards, including two fourth-quarter scores.
BOSTON COLLEGE 42,
RHODE ISLAND 0
In Boston, Montel Harris ran for 143 yards and three touchdowns to lead Boston College in the schools' first meeting since 1917.
Backup quarterback Dominique Davis added a 24-yard touchdown run for the Eagles (3-1).