The loss is a huge setback for a team that has Super Bowl expectations.
"Shawne informed me he did not feel right and thought it best to shut it down," Chargers general manager A.J. Smith said in a statement.
"The road to winning the AFC West just got more difficult, but not impossible. Nothing is impossible. Shawne is a great player and an inspirational leader. He will be missed. We wish him a successful surgery and a speedy recovery."
JAGUARS: The lead detective in the shooting of tackle Richard Collier says investigators believe the player was targeted.
Sheriff's Detective Dennis Sullivan says Collier remains in critical but stable condition at a Jacksonville, Fla. hospital, with multiple gunshot wounds. He was shot in his car outside an apartment last Tuesday.
Police said Collier's teammates and friends added $10,000 to the usual $1,000 reward for information on the assailant.
- Signed guards Milford Brown and Chad Slaughter after placing Vince Manuwai on injured reserve (torn ACL) and losing Maurice Williams (ruptured biceps).
PATRIOTS: Coach Bill Belichick said he's in no rush to sign a new quarterback, one day after losing MVP Tom Brady for the season with a knee injury.
The coach said Tim Rattay and Chris Simms (who signed with Tennessee Tuesday) were in Foxborough on Monday, but didn't work out or take physicals.
It appears the team will go into Sunday's game with two quarterbacks -- veteran backup Matt Cassel and rookie Kevin O'Connell .
SEAHAWKS: Ryan Plackemeier , the punter who won the Ray Guy Award in 2005, running back Justin Forsett and wide receiver Jordan Kent have been released.
Seattle has only two healthy wide receivers -- Courtney Taylor and Logan Payne -- for Sunday's game against the 49ers. Receiver Nate Burleson was placed on IR on Tuesday, and Deion Branch and Bobby Engram are not expected back for a few more weeks.
Veteran Jon Ryan was signed to take Plackemeier's spot.
STEELERS: Quarterback Ben Roethlisberger will be limited in practice because of a sore shoulder but is expected to play Sunday.