Franzen scored three times to lift Detroit to a 5-1 victory Saturday over the banged-up Avs, giving the NHL's top-seeded team a 2-0 lead in the Western Conference semifinals.
Franzen redirected a shot in front of the net early in the game, scored on a wraparound in the second period, and whacked a rebound out of the air in the third for his first career hat trick.
He had two goals in Detroit's series-opening win.
Colorado's Ian Laperriere scored early in the third period.
Game 3 is Tuesday night in Colorado.
Colorado's Jose Theodore gave up four goals on 20 shots and was pulled for a second consecutive game. Peter Budaj finished with 19 saves.
Colorado was without center Peter Forsberg (groin), defenseman Scott Hannan (lower-body injury) and winger Wojtek Wolski (upper-body injury).
Theodore was back on the ice after being replaced in Game 1 because he was sick, but he didn't last long in Game 2.
The Red Wings chased him midway in the second period after Franzen scored his first two goals and Valtteri Filppula and Henrik Zetterberg added goals.
At the other end, Detroit didn't give the Avs much of a chance to have success.
Detroit's defense held Colo-rado to only 20 shots as it opened up the offense to take more chances trying to come back.