The Lady Tigers led the No. 12 Blue Devils (19-6, 8-2 Atlantic Coast Conference) 12-4 six minutes into the game, but Duke went on a 36-5 run to finish the half and take a 40-17 lead at the break.
The Lady Tigers (10-15, 3-7) shot just 7-for-36 (19.4 percent) in the first half.
Christy Brown led the Lady Tigers with 11 points, while D'Lesha Lloyd added 10 points to top 1,000 points for her career.
NO. 11 WEST VIRGINIA 56, NO. 18 PITTSBURGH 35
In Morgantown, W.Va., Olayinka Sanni scored 17 points, and West Virginia used 16-2 runs in each half to beat Pittsburgh.
Meg Bulger added 14 points for the Mountaineers (20-3, 9-1 Big East), who reached 20 wins for the fourth time in five seasons.
Pittsburgh (18-6, 8-3) was held to a season-low 20 percent shooting (12 of 59) from the field.
NO. 14 GEORGE WASHINGTON 69, MASSACHUSETTS 45
In Amherst, Mass., Jessica Adair scored 14 points to lead four George Washington players in double figures as the Colonials beat Massachusetts.
The Colonials played without starting guard Kimberly Beck, who was sick, ending her streak of 107 starts and 119 games played.
NO. 16 NOTRE DAME 99, MARQUETTE 76
In South Bend, Ind., Tulyah Gaines scored a season-high 22 points, and Notre Dame took control with a 21-1 run midway through the first half.
Marquette (13-11, 5-6) jumped to an early 23-17 lead, but the Fighting Irish (19-5, 7-3) switched to a box-and-one defense, and the Golden Eagles went more than 9 minutes without a basket.
NO. 17 KANSAS STATE 45, IOWA STATE 42
In Ames, Iowa, Kimberly Dietz scored 18 of her 20 points in the first half, and Kansas State held off Iowa State's second-half charge for a victory.
Kansas State (17-6, 9-1 Big 12) has won 12 of 13 and remained tied with Baylor for first in the league.
NO. 21 SYRACUSE 81, SETON HALL 72
In South Orange, N.J., freshman Erica Morrow scored 23 points, including five 3-pointers, to lead Syracuse over pesky Seton Hall.
Fantasia Goodwin added 20 points and Chandrea Jones had 13 for Syracuse (19-4, 7-3 Big East).
TCU 73, NO. 22 WYOMING 59
In Fort Worth, Texas, Adrianne Ross scored 21 points, and Helen Roden added 15 to help TCU win its fifth consecutive game.
TCU (15-9, 8-2 Mountain West) lost 62-45 to Wyoming on Jan. 12.
The Lady Frogs stormed out to a 39-24 advantage at the half.
Wyoming (19-4, 7-3) lost for the third time in four games.