Oklahoma State had speed, skill and Zac Robinson.
Robinson threw three touchdown passes and ran for two scores, leading the Cowboys to a 49-33 Insight Bowl victory over the Hoosiers on Monday night.
"We did feel like we were faster than Indiana, if we got our skill players some space," Oklahoma State coach Mike Gundy said.
Robinson completed 24 of 34 passes for 302 yards, and threw an interception. He also ran for 70 yards.
Dantrell Savage ran for 100 yards and a touchdown for the Cowboys (7-6), who matched their season-high point total. Dez Bryant caught nine passes for 117 yards and two touchdowns.
The Cowboys spotted Indiana an early field goal, then scored touchdowns on their first five possessions to take a 35-10 halftime lead.
The loss capped an emotional year for the Hoosiers (7-6), making their first bowl appearance since 1993. Indiana was playing to honor the memory of coach Terry Hoeppner, who died in June of complications of a brain tumor.
Kellen Lewis passed for 204 yards and two touchdowns, and ran for 83 yards and a touchdown for the Hoosiers.
"We came here to win and play it to the end, and so we did," Indiana coach Bill Lynch said. "I was proud of our kids about that."
Appearing in a minor bowl for the fourth time in six years, the Cowboys answered questions about whether they would be as motivated as the Hoosiers.
"They made up their minds two weeks ago," Gundy said. "They wanted to practice hard. They wanted to go out winners, and the senior class wanted to find a way to get it done. They did. They played with great enthusiasm early in the game."