Bud Selig does not plan to attend the news conference at a Manhattan hotel a few blocks from the commissioner's office.
Mitchell said Wednesday he will release his report then, and it will be posted online at MLB.com shortly after that. Selig will hold his own news conference 21/2 hours after the one by Mitchell.
Baseball officials have said for several weeks that management would be able to examine the report on performance-enhancing drugs a few days before it is made public to make sure it does not contain confidential information that if released would violate the collective bargaining agreement between players and owners.
Mitchell is expected by many in baseball to be critical of the sport for being slow to react to its drug problem in 1990s and beyond.
What they will be looking to see in his report is how he parcels blame among Selig, club owners, general managers, other team employees, the players' association and players themselves.
The revelation of players who have not yet been publicly linked to drug use figures to be the most sensational part of the report. Media reports have linked an array of All-Stars and MVPs to performance-enhancers in recent years, among them Barry Bonds , Jose Canseco , Juan Gonzalez , Mark McGwire and the late Ken Caminiti .
DODGERS: Andruw Jones was introduced at a news conference in Los Angeles, a week after the sides agreed to a $36.2 million, two-year contract.
Regarding the Atlanta Braves' refusal to make him an offer, Jones said: "This is a business. My mind was set to finish my career with the Braves. Being in Atlanta for 11 years, I appreciate everything they did for me. Nothing against the Braves."
PADRES: Cy Young Award winner Jake Peavy signed a $52 million, three-year extension with San Diego, the biggest deal in Padres history.
GIANTS: Aaron Rowand agreed to a $60 million, five-year contract with San Francisco, giving the club the starting center fielder it sought this winter.
YANKEES: Andy Pettitte and New York agreed to a $16 million, one-year contract.
CUBS: Japanese outfielder Kosuke Fukudome and Chicago reached a preliminary agreement on a $48 million, four-year contract. The deal is subject to a physical that is expected to take place next week.
CARDINALS: Signed Hall of Fame pitcher Bob Gibson's son, Chris , and relief pitcher Randy Flores' younger brother, Ron .