Langer's 17-under 127 total broke the 36-hole tournament record of 128 set by defending champion Jay Haas last year and gave the two-time Masters Tournament champion a comfortable margin over Mark O'Meara, another former Masters champion, and Texan Tom Kite.
O'Meara, who started the day five shots behind, had an 8-under 64 for a 13-under 131 total. Kite, trying to win his first tournament in his home state, shot a 65.
Langer's second-round start wasn't as impressive as the first round when he birdied the first hole and eagled the par-5 second. On Saturday, he started par-bogey, but birdied the next hole and had two more birdies at Nos. 5 and 7. He added five birdies on the back nine, including three in a row to finish his round.
Langer is playing in his fourth senior event since turning 50 on Aug. 27. He set the course record with 62 on Friday.
EUROPEAN TOUR: Daniel Vancsik shot 4-under 68 to hold a two-shot lead after the third round of the Madrid Open.
Vancsik, who had nine birdies, three bogeys and a double bogey, was at 13-under 203. Mads Vibe-Hastrup was second after a 67.
NATIONWIDE TOUR: In Midland, Texas, Greg Chalmers (71) and Briand Guetz 70) are tied at 12-under 204 entering today's final round of the WNB Golf Classic at Midland Country Club. John Riggier (69) is a stroke back.