Ole Miss quarterback Seth Adams completed a 41-yard pass to Shay Hodge to give the Rebels possession at the Alabama 4 with 7 seconds left.
After a 5-minute review that clearly showed Hodge stepped out of bounds and returned to the field to make the catch, the play was ruled illegal and Alabama (5-2, 3-1 Southeastern Conference) took over on downs for a final snap to seal the victory.
Ole Miss (2-5, 0-4) has lost three in a row to Alabama, each by three points.
Leigh Tiffin put Alabama ahead with a 24-yard field goal with 5:14 left that was set up by an interception by Ezekial Knight. Alabama tied the game on the previous possession on a 3-yard touchdown run by Terry Grant with 7:11 remaining.
Wilson went 26-for-40 and D.J. Hall pulled down 11 receptions for 140 yards. Alabama finished with 420 yards of total offense, but was plagued by two second-half turnovers and a blocked punt that gave the Rebels a 24-17 lead into the final period.
BenJarvis Green-Ellis ran for 131 yards on 20 carries and Adams was 22-for-40 for 284 yards and two touchdown passes for the Rebels.
NO. 22 AUBURN 9, ARKANSAS 7
In Fayetteville, Ark., Wes Byrum kicked his second game-winning field goal in three weeks, this one from 20 yards with 21 seconds remaining .
Byrum, a freshman, kicked a 43-yard field goal as time expired two weekends ago for a 20-17 win over Florida.
The Tigers (5-2, 3-1) are tied for first in the SEC West with Alabama and LSU. Auburn is at LSU next week.
The Tigers held Darren McFadden to 43 yards rushing, the first time all season he's been under 100.
Arkansas (3-3, 0-3) took a 7-6 lead with 1:36 remaining on Casey Dick's 13-yard touchdown pass to Lucas Miller.
NO. 25 TENNESSEE 33, MISSISSIPPI STATE 21
In Starkville, Miss., Eric Ainge threw for 259 yards and two touchdown passes and Lucas Taylor had career highs of 11 catches for 186 yards Saturday to lead Tennessee to a victory over Mississippi State.
The Volunteers (4-2, 2-1) fell behind the Bulldogs (4-3, 1-3) 14-7 early, but Ainge hit Taylor for a 51-yard touchdown in the second quarter that started the rally and Arian Foster scored on a 1-yard run after a personal foul penalty in the third quarter to help Tennessee pull away.
Daniel Lincoln also made four field goals to nail down Tennessee's third consecutive win and the fourth in its past five games.