A couple of holes later, a huge oak tree taught him a lesson.
Quigley scrambled to save par at No. 13 - the second-easiest hole - and that contributed to him losing the lead Friday.
He shot 3-under-par 69 and finished the second round in a tie for first place with Jim Furyk and Kenny Perry at 10-under 134.
"I tried to force the issue," Quigley acknowledged. "I knew if I could make four or five birdies, I might have a pretty good lead. As a result, I started thinking about results instead of staying in my process and got ahead of myself and came back to the field."
The cut was 3-under 141. Among those who didn't make it was Augusta's Charles Howell, sixth in FedEx Cup points. He shot 73 and finished at 142.
Aiken's Matt Hendrix also missed the cut, shooting 79 to finish at 151.
Quigley and Furyk (68) had solid rounds after starting the day among the leaders while Perry's 9-under 63 lifted him from a tie for 73rd.
Perry matched his low round of the year. His last 63 closed the Memorial earlier this month, helping him finish third for his only top-10 finish since 2005.
Quigley was 4 under through 10 holes, giving him a two-shot lead over Furyk.
Following a long delay at the 13th tee, Quigley's drive to the right landed behind a tree. Quigley summoned a rules official, who said he could not have relief.
Quigley thought about hitting onto an adjacent hole and back to the 13th green, but chose to chip into the fairway - putting him just 5 yards closer to the pin - and ended up two-putting.
He then bogeyed No. 16, which is among the easier holes on one of the Tour's most vulnerable courses.