Humphrey scored 10 points in a late 13-0 run to finish with 25 points and lead No. 16 Georgia to a come-from-behind 70-65 win over Florida State on Sunday.
Humphrey, playing with four fouls in the closing run, consistently overwhelmed Florida State's young inside players.
"Tasha Humphrey is an All-America candidate and she showed why," said Shante Williams, who led Florida State with 19 points.
With the 13-0 run, the Lady Bulldogs (16-4) turned a 60-50 deficit into a 63-60 lead.
Angel Robinson added 16 points for Georgia.
Williams scored 15 second-half points for Florida State (15-4) but had too little help as the Seminoles couldn't stop Humphrey, who avoided the fifth foul.
"It was just me playing smarter," Humphrey said. "It was a physical game. I got caught in a pushing and shoving match and I knew if I kept doing that I would end up on the bench."
Florida State's biggest lead was 29-14 late in the first half, and the lead was still 10 points before Georgia's 13 unanswered points.
"That was probably our best 35 minutes we've played," said Florida State coach Sue Semrau.
"Tasha Humphrey is a great player and down the stretch I thought she was the difference-maker."
Tanae Davis-Dain scored 13 points, all in the first half, for Florida State. Mara Freshour added 11.
Humphrey scored the first seven points of the game before Florida State got going.
Only two games after being held to a season-low 18 first-half points in a 52-41 loss to Tennessee, Georgia trailed Florida State 33-21 at halftime. The Lady Bulldogs, 2-for-13 on 3-pointers, made only 24.7 percent of their shots from the field.
Florida State led 37-28 with 14:47 left to play when Humphrey left with her fourth foul. The Seminoles stretched the lead back to 13 points before Georgia began its comeback with Humphrey still on the bench.
A basket by Robinson cut the Seminoles' lead to 49-45, but Florida State stretched the advantage back to 10 points at 60-50.
Humphrey, who returned with 6:44 left to play, scored on three straight possessions as Georgia pulled even at 60-all. Hardrick followed with a layup for the Lady Bulldogs' first lead since early in the game.
Georgia coach Andy Landers said Robinson's play allowed him to keep Humphrey on the bench for about eight minutes in the second half.
"We're still a work in progress," Landers said. "You can see that. We're at the midpoint in January and I was hoping we'd be there at this point, but we're not."
Added Landers: "We're not that far away."
Landers said the comeback could help the Lady Bulldogs when they return to Southeastern Conference games.
"To be able to win, I think it could send us in a direction we haven't been in all year," Landers said. "We may have had a cleansing today."
Florida State is 5-0 in the Atlantic Coast Conference but had not played a Top 25 team before facing Georgia.
Georgia moved to 6-0 in its all-time series with the Seminoles.
The game was the first of two SEC-ACC games in the Russell Athletic Shootout at the Gwinnett Center, the site of this season's SEC tournament.