Camille Little added 12 points and Jessica Breland 10 for North Carolina (21-0, 5-0 Atlantic Coast Conference).
Reserve Jacqua Williams scored 11 to lead the Yellow Jack-ets (11-7, 2-3), who had no starter with more than four points.
It was the fewest points North Carolina has allowed any ACC opponent and the Tar Heels' biggest margin of victory in their series with Georgia Tech.
Georgia Tech was 11 of 59 from the field (18.6 percent).
The Yellow Jackets hit just eight of their first 36 shots and had more turnovers (13) than field goals in the first half.
North Carolina hit 12 of its first 17 shots in the second half and finished 29 of 62 from the field.
NO. 1 DUKE 65, NORTH CAROLINA STATE 51
In Raleigh, N.C., freshman Brittany Mitch scored eight of her 10 points during a decisive spurt that helped Duke dodge a letdown.
Playing for the first time since upsetting Maryland and taking over the top spot in the rankings, the Blue Devils (19-0, 5-0 Atlantic Coast Conference) shook off a slow start and used a 27-8 run that bridged halftime to take command and remain one of two unbeaten teams in both the country and the conference.
Lindsey Harding added 10 points for Duke, which shot 43 percent and led by 21 in its 10th consecutive victory against the Wolfpack.
Gillian Goring had 15 points and 10 rebounds to lead N.C. State (13-6, 2-2), which had its 10-game home winning streak snapped.
NO. 4 TENNESSEE 73, MISSISSIPPI STATE 44
In Knoxville, Tenn., fourth-ranked Tennessee got a glimpse of life without Candace Parker, when Sidney Spencer scored 18 points and Shannon Bobbitt added 13 in a rout.
Team officials said Parker did not play because she was sick. She sat on the bench with her teammates wearing her warm-up suit during the game.
Alex Fuller, who started in place of Parker, and Alexis Horn-buckle each had 12 points for Tennessee (17-1, 4-0 Southeastern Conference).
Marneshia Richard led Mississippi State (10-8, 1-3) with 14.
NO. 16 GEORGIA 83, NO. 14 VANDERBILT 71
In Athens, Ashley Houts scored a career-high 21 points and Georgia broke open a close game with a 10-0 second-half run.
Georgia, coming off a 52-41 home loss to No. 4 Tennessee, regrouped offensively with four players hitting double figures.
Tasha Humphrey scored 18 points and Janese Hardrick added 17 points and eight rebounds for Georgia (15-4, 3-2 Southeastern Conference).
Christy Marshall was 7-for-8 from the free-throw line in the last 3 minutes and added 13 points for Georgia.
Christina Wirth led Vanderbilt (16-3, 3-2) with 16 points. Merideth Marsh, Caroline Williams and Carla Thomas each added 12 points, but couldn't keep the Commodores from falling to 2-2 against ranked teams.
Vanderbilt, led by Williams' nine points on three 3-pointers, led 30-29 at halftime. Georgia shot only 31.3 percent from the field, but stayed close on Humphrey's nine points, also on a season-high three 3-pointers.
With the 6-foot-3 Humphrey moving her scoring inside, Geor-gia took the lead early in the second half.
Megan Darrah rebounded a missed free throw by Marshall. Darrah's three-point play, followed by a steal and basket by Hardrick, gave Georgia a 48-39 advantage.
Vanderbilt pulled within 50-46 before Georgia pulled away with its 10-0 run for a 60-46 lead with 6:42 left to play.