Originally created 02/14/98

Scientist says proof will come that Dolly was cloned



PHILADELPHIA -- The scientist credited with creating the first adult clone hinted Friday that he may be repeating the experiment to silence critics who say Dolly the sheep may not have come from an adult cell.

Responding to suggestions that Dolly may not be a true adult clone because no lab has been able to duplicate the experiment, Ian Wilmuth of the Roslin Institute in Scotland urged patience.

"It is too premature" to dismiss his claim, Wilmuth said, speaking at the American Association for the Advancement of Science. "There hasn't been time for other labs to complete their work and get it published."

Asked why he hasn't duplicated the Dolly experiment, Wilmuth replied, "Perhaps we are." He did not elaborate and would not respond to further questions.

Wilmuth stunned the world last year by announcing that he had cloned Dolly using the nucleus from the cell of an adult sheep. It marked the first time that a genetically identical mammal had been created from an adult cell. And it set off a worldwide debate about the ethics of cloning humans.

President Clinton issued orders that no federal dollars could be spent to attempt to clone humans and several bills that would ban or put a moratorium on human cloning have been introduced in Congress. At least 20 states also are considering such laws.

But last month, two researchers suggested in a letter to the journal Science that Wilmuth's claim about Dolly could be false.

Dr. Norton Zinder of Rockefeller University and Dr. Vittorio Sgaramella of the University of Calabria in Italy questioned the credibility of the Wilmuth's claim because at least three labs have failed in attempts to duplicate the work. They also questioned why the Scottish lab has not repeated the experiment. Scientific experiments usually must be repeated before they are verified and accepted by other scientists.

The Dolly claim also has been challenged because the frozen specimen came from a pregnant sheep and it is possible that a fetal cell in the sheep's blood could have supplied the genes that created the clone. Fetal clones have been performed by a number of labs.

Wilmuth said it is "extraordinarily unlikely" that Dolly came from a fetal cell because such cells in the maternal blood are rare -- only one among several million adult cells.

The Scottish scientist said he remains opposed to attempting to clone humans.

"I have not heard a reason for doing that that I find ethically acceptable," he said.

Another speaker at the conference, Lori Andrews of the Chicago College of Law, said some of the state legislation seeking to forbid human cloning would leave loopholes permitting it.

For instance, experiments have shown that eggs from cows could be used "as universal incubators" for human clones, and at least eight proposed state laws would not forbid this practice.

She said it also is possible to clone using a very early human embryo, which would be permitted under loopholes in six proposed state laws.