Brees passed for 413 yards and four touchdowns, and the Saints turned a clash of unbeaten teams into a lopsided affair, beating the Miami Dolphins 38-17 on Monday night.
Two of Brees’ touchdowns went to Jimmy Graham for 27 and 43 yards as the tight end had at least 100 yards receiving for the third consecutive game.
Brees’ other scoring strikes went to Benjamin Watson and Darren Sproles, who also rushed for a touchdown.
Sproles’ 5-yard scoring run on the game’s opening series gave the Saints a lead they would not relinquish en route to their first 4-0 start since their Super Bowl championship season of 2009.
Ryan Tannehill passed for 249 yards and a touchdown to Charles Clay, but his four turnovers on a fumble and three interceptions hurt Miami (3-1).
The Saints have won their past nine Monday night games, all with Brees at quarterback.
Brees’ his 10th 400-yard outing since he joined the Saints in 2006 delivered a sobering blow to a Miami team that came in riding a surprising start. He was 30 of 39 against Miami without an interception. Sproles caught seven passes for 114 yards. Marques Colston had seven catches for 96 yards.
Miami’s Lamar Miller had 62 yards rushing on 11 carries.
When Brees was a free agent in 2006, he drew the most interest from New Orleans and Miami, but the Dolphins, fearful of the effects of reconstructive surgery on Brees throwing shoulder, did not pursue the quarterback as enthusiastically as then-Saints rookie coach Sean Payton. Since then, Brees has become one of the most prolific quarterbacks in NFL history.
As the Saints pulled away, they also turned up their pass rush, sacking Tannehill three times in the third quarter.
Brees completed his first three passes for 70 yards. He followed up his long pass to Sproles with an 18-yard completion to rookie Kenny Stills. Soon after, Sproles ran it in, untouched, on a draw play.
During the drive, Brees became only the seventh quarterback to pass for more than 47,000 yards. He ended the drive with 47,030, surpassing Fran Tarkenton’s 47,003 for sixth most yards passing all-time.
Later, Brees’ eighth completion gave him 4,124 in his career, one more than John Elway for fourth all-time in that category.
Miami responded quickly to New Orleans opening score, surprisingly by running the ball. The Dolphins came in averaging 70.3 yards rushing per game, but gained 57 on the ground on their opening series. Miller had 33 yards on one run and Tannehill had a 26-yard gain.
However, New Orleans’ defense tightened up at its 10-yard line, and rookie nose tackle John Jenkins’ tackle behind the line forced Miami to settle for Caleb Sturgis’ 34-yard field goal.
Miami was driving for a potential go-ahead score when Tannehill tried to scramble up the middle and was stripped by linebacker Curtis Lofton. Safety Rafael Bush recovered on the New Orleans 38. That set up a drive that ended with Graham’s leaping, juggling catch as three defenders converged on him.
Later in the half, Jabari Greer intercepted a pass intended for Brian Hartline, and returned it 22 yards to the Miami 23. Several plays later, Sproles made a catch along the left sideline, spun away from a converging defender and scored his second touchdown with 55 seconds left in the half to make it 21-10.