The Broncos (3-0) have outscored opponents 127-71 this season.
Manning hit Eric Decker, Wes Welker and Julius Thomas for a score apiece.
The quarterback’s 12 TD passes are an NFL record for the opening three games, breaking Tom Brady’s mark of 11 in 2011. Manning has yet to throw an interception this year.
Oakland’s Terrelle Pryor finished 19 for 28 for 281 yards but played catch-up from the start.
Oakland (1-2) trailed 17-0 before Pryor hit Denarius Moore for a 73-yard score.
Four plays later, Manning connected with Thomas for a 13-yard score to push the lead back to 17.
The Broncos’ win might have come at a cost.
Defensive backs Duke Ihenacho and Tony Carter left the game with ankle injuries.
Carter, the Broncos’ nickel back, was injured in the first half and Ihenacho, a second-year safety who also left last week’s game against the New York Giants with an ankle injury, left in the third quarter.
Cornerbacks Champ Bailey (foot) and Quentin Jammer (healthy scratch) were inactive.
Denver has a short week to prepare for the Philadelphia Eagles’ visit next week.
The Raiders-Broncos game marked a record 17th Monday night meeting between the longtime rivals.