The Falcons moved to the brink of clinching the NFC South and dealt a big blow to the Saints (5-7) and their fading playoff hopes.
William Moore had two of the five interceptions, which were the most of Brees’ career and came four days after he had two passes picked off and returned for touchdowns in a loss to San Francisco.
Brees had thrown a touchdown pass in 54 consecutive games.
He had an apparent scoring pass to Darren Sproles late in the first half, but it was nullified by a penalty.
Michael Turner scored on Atlanta’s opening possession, Tony Gonzalez hauled in a touchdown pass from Matt Ryan, and Matt Bryant booted three field goals, including a 55-yarder. He also kicked a 45-yarder and a 29-yarder.
The Falcons defense did the rest.
Thomas DeCoud, Sean Weatherspoon and Jonathan Babineaux also had interceptions for Atlanta, which will clinch the NFC South with a month to go in the regular season if Tampa Bay loses to Denver on Sunday.
Brees had a couple of games with four picks, but nothing like this. He finished 28 of 50 for 341 yards.
The defending NFC South champion Saints lost their second in a row and will likely have to win out to have even a faint hope of making the postseason during a tumultuous year that was marred by a bounty scandal and a season-long suspension for coach Sean Payton.
After winning so many close games, the Falcons started this one as if they were intent on a rout.
Ryan completed a pass on the first play from scrimmage, then turned it over to a running game that has struggled most of the season. Turner burst around right end for a 35-yard gain. Jacquizz Rodgers broke off two straight 14-yard gains. Finally, it was Turner going in standing from 3 yards out, giving Atlanta a quick 7-0 lead.
That was Turner’s 58th touchdown in five seasons with the Falcons, breaking the team record he had shared with Terance Mathis.
Turner ended the night with 83 yards on the ground on 12 carries.
Turner also has the team record with 57 rushing touchdowns.
He caught his first career touchdown pass in Week 4 against Carolina.