Nick Foles received a big ovation Sunday when he took over with the game tied 7-7 in the second quarter.
Vick was hit by linebacker Ernie Sims on an incomplete pass and was slow to get up.
Vick had 2,095 yards passing, 10 touchdowns and nine interceptions entering the game.
49ERS: Alex Smith left game against the St. Louis Rams with a concussion.
Smith scrambled and started to slide before turning his back late, and linebacker Jo-Lonn Dunbar barreled into his neck area with 1:10 left in the first quarter Sunday. Smith briefly grabbed his facemask and grimaced but stayed in the game, throwing a 14-yard touchdown pass to Michael Crabtree in the second quarter.
Colin Kaepernick replaced Smith on San Francisco’s next possession.
BRONCOS: Peyton Manning threw his 420th career touchdown pass in the first quarter against the Carolina Panthers to move into a tie with Dan Marino for the second-most touchdown passes in NFL history.
Manning tied the record on a 14-yard touchdown pass to Brandon Stokely.
Brett Favre has the most TD passes in NFL history with 508.
GIANTS: Receiver Domenik Hixon suffered an ankle injury in the first quarter of a game against Cincinnati and didn’t return.