Darius Butler returned an interception for a score as the Colts (6-3) won their fourth consecutive game and snapped a three-game losing streak in the series. The Jaguars (1-8) have lost six in a row.
The Colts had cause for concern after an emotional victory four days earlier, one in which cancer-stricken coach Chuck Pagano delivered a passionate, postgame speech in the locker room. Interim coach Bruce Arians was worried the team might crash from the emotional high.
Not even close.
Indianapolis scored on three consecutive possessions in the first half, opening a 17-0 lead that started emptying the stands at EverBank Field.
Butler’s interception was the second big defensive play of the game for the cornerback, who recovered a fumble in the second quarter that led to a score.
Luck was surgical in the opening half, keeping drives alive with several long passes.
He scored on a close fourth-and-goal sneak for his second touchdown, prompting Jacksonville coach Mike Mularkey to throw his play sheet as he ran onto the field arguing for a review.
Luck threw for 227 yards.