Edwards tweeted the news Tuesday, attributing the move to his injury, which “required more time to rehab and hasn’t allowed me to re-sync with the offense.”
The 49ers confirmed Edwards’ release.
Edwards had 15 catches for 181 yards and no touchdowns in eight games with five starts for the NFC West champion 49ers (12-3) after receiving a $3.5 million, one-year contract in August.
PACKERS: A mid-February trial date has been set for linebacker Erik Walden on a disorderly conduct-domestic abuse charge.
He pleaded not guilty to the misdemeanor, which stems from a dispute with his girlfriend in November.
A judge Tuesday set a trial date of Feb. 16, which is 11 days after the Super Bowl.
NFL spokesman Greg Aiello said in an e-mail to The Associated Press that the league will review the matter after the court case is resolved.
BENGALS: Placed wide receiver Andre Caldwell on injured reserve with a hernia.
The fourth-year player saw action in 13 games this season with two starts, making 37 catches for 317 yards and three touchdowns.
To replace Caldwell, the Bengals signed rookie receiver Armon Binns from the practice squad.
PATRIOTS: Signed seven-year NFL veteran fullback Lousaka Polite.
Polite, 30, has played for Dallas (2004-06), Chicago (2007) and Miami (2008-10). He went to training camp with the Dolphins last summer but was released on Sept. 3.
LIONS: Signed running back Joique Bell and released running back Aaron Brown.
The Lions might use Bell on Sunday at Green Bay to rest Kevin Smith, who has been slowed by a sprained right ankle, for the playoffs.
BEARS: Placed quarterback Jay Cutler and running back Matt Forte on injured reserve, meaning they will miss the season finale at Minnesota this week.
REDSKINS: Released running back Ryan Torain, who started four games this season, but fell behind rookies Roy Helu and Evan Royster on the depth chart.
Torain rushed for only 200 yards this year, with 135 coming in the win over the St. Louis on Oct. 2. He then struggled when given a shot at starting after Tim Hightower was lost for the season with a knee injury, leading to the emergence of the rookies.