Dan Orlovsky threw one touchdown pass, a key block on an 80-yard TD run and the Colts defense held Chris Johnson to 55 yards rushing, to beat Tennessee 27-13 and avoid becoming the second 0-16 team in league history.
Indy's players threw their arms in the air after making a fourth-down stop with less than 2 minutes to go, and the fans still around cheered loudly as the Colts (1-13) ended a 14-game losing streak.
For the first time in 10 career starts, Orlovsky finished the game with the traditional kneel down, and the Colts also avoided becoming the first team in franchise history to go 0-14.
The Colts' previous win had come Jan. 2 of last season, also at home against Tennessee.
For the Titans (7-7), the loss was a devastating blow to their playoff hopes.
Had the Titans closed out the season with three wins, they likely would have reached the postseason. Now they'll need to win their last two games and probably need help from other teams just to get in.
Tennessee had nobody to blame but itself for this stumble. Matt Hasselbeck was picked off twice before being pulled in favor of rookie Jake Locker. Johnson ran 15 times for 55 yards.
The Titans also lost a fumble and booted a kickoff out of bounds at their own 1. And even after Locker threw a 7-yard TD pass to Nate Washington with less than 4 minutes to go, they couldn't wrap up the Colts.
Orlovsky went 11 of 17 for 82 yards.