Carlos Boozer missed a 3-point attempt that could have tied the game with a second remaining.
Indiana never trailed and finally broke through after losing the first three games by a combined 15 points.
GRIZZLIES 91, SPURS 88
In Memphis, Tenn., Zach Randolph scored 25 points, including a rare 3-pointer with 41.9 seconds left, and Memphis beat San Antonio for the franchise's first playoff victory on its home court.
These Grizzlies have been busy this postseason making lots of history at the Spurs' expense. They opened this series with their first playoff win, and now the No. 8 seed has a 2-1 lead over the NBA's best team during the regular season.
Memphis is trying to become just the fourth team to knock off the top-seeded team.
TRAIL BLAZERS 84, MAVERICKS 82
In Portland, Ore., Brandon Roy's go-ahead bank shot with 39.2 seconds left capped Portland's 23-point second half comeback and the Blazers beat Dallas, evening the first-round playoff series at two games apiece.
Roy, who had arthroscopic surgery on both knees in January, had 18 of his 24 points in the fourth quarter alone.