Wade also finished with 12 rebounds for the Heat, who bounced back from a loss to Boston on Sunday.
LeBron James scored 10 of his 27 points in the fourth quarter and Chris Bosh added 22 points and eight rebounds for Miami, which has won eight of nine.
Roy Hibbert scored 18 points and Tyler Hansbrough added 16 for the Pacers. Indiana has won seven of nine under interim coach Frank Vogel, with both losses coming against the Heat.
Miami led by 24 points in the first half, then lost the lead before regaining it for good in the fourth quarter.
GRIZZLIES 102, 76ERS 91
In Memphis, Tenn., Mike Conley scored all 22 of his points in the second half, helping Memphis hold off Philadelphia.
Zach Randolph had 21 points and 10 rebounds for Memphis, along with a season-high seven assists as Memphis won its fourth in a row. Sam Young added 12 points and Rudy Gay had 11 before leaving in the second quarter with a shoulder injury.
BULLS 106, BOBCATS 94
In Chicago, Luol Deng scored 24 points, Derrick Rose had 18 points and 13 assists after a slow start, and Chicago beat pesky Charlotte for its ninth win in 11 games.
In a game of momentum swings, the Bulls needed a strong finish to pull this one out and put away a team that blew out the Lakers the previous night.
THUNDER 126, KINGS 94
In Oklahoma City, Okla., Daequan Cook scored 20 points and Russell Westbrook added 10 points and 11 assists as Oklahoma City set a season high for points.
Oklahoma City scored 68 points in the first half, a season-high for a half, and led by as many 25 before leading by 18 at the halftime break as the Thunder topped the Kings for the second time in four days. Oklahoma City beat Sacramento 99-97 on Saturday.
Kevin Durant went 5 for 18 from the field and scored 17 points.