Briere had his second chance at the winner count minutes after his earlier attempt was overturned on review because he kicked it into the net. He also scored in the second period.
He wasted no time making it up for the OT missed opportunity. He fired a slapper past Martin Brodeur for his seventh goal of the playoffs. Brodeur was screened in front by Philadelphia forward James van Riemsdyk.
The Flyers took the series lead in their first game in a week after eliminating Pittsburgh in six games. The Devils played their third consecutive overtime game after defeating Florida in Games 6 and 7 to win the first-round series.
COYOTES 5, PREDATORS 3
In Glendale, Ariz., Shane Doan, Radim Vrbata and Antoine Vermette each had a goal and an assist, and Phoenix avoided its usual overtime theatrics, beating Nashville to take a 2-0 lead in the Western Conference semifinal series.
Martin Hanzal and Taylor Pyatt also scored for the Coyotes. Ryan Suter, Patric Hornqvist and Andrei Kostitsyn scored for the Predators.
Phoenix scored three times on 19 second-period shots. The Coyotes built a two-goal lead early in the second period. Nashville twice cut it to one only to see Phoenix quickly respond.
The Coyotes did not go into overtime for only the second time in eight playoff games.
The best-of-seven series shifts to Nashville for Game 3 on Wednesday night.