Tied with Washington County and with the ball to start the third quarter, the Bulldogs had a great chance to start 6-0 for the first time.
Instead, turnovers and short possessions proved costly as a 14-14 game turned into a 42-14 defeat.
Despite the tough loss, players remained on the field after the game for a bit and later went through a team cheer.
Washington County coach Joel Ingram gave a lot of credit to the Bulldogs for keeping the Golden Hawks out of rhythm for much of the game.
Butler coach Ashley Harden pointed to the positives from a game that was played almost even for most of the contest.
"We still have heart," Harden said. "We didn't give up."
TALENTED FOE: Fox Creek's 50-0 loss to Calhoun County was its worst since a 58-0 defeat to Williston-Elko in Week 5 last season.
Friday's loss came thanks to Saints quarterback Shamier Jeffery , who threw for 321 yards and five touchdowns.
The senior is the brother of South Carolina receiver Alshon Jeffery .
"He lives up to his name," Calhoun County coach Walt Wilson said.
Shamier completed 22 of 30 passes against Fox Creek and threw three scores on two-point conversion attempts.
ROLLING ALONG: Burke County has played four games against fellow Region 3-AAA schools, including two in subregion play.
None of those four teams have finished within 36 points.
In beating Josey, Westside, Glenn Hills and Hephzibah, the Bears have outscored region foes 240-43.
In the past three games, Burke County has averaged 61 points -- the highest average in a three-game span in program history.
BIG GAMES THIS WEEK
Evans (4-2) at Statesboro (6-1)
The Knights took an upset loss to Greenbrier on Friday and now face Statesboro, a squad unbeaten in subregion play in 2-AAAA. Evans won the most recent meeting in 2007 for its first victory in the series.
Josey (3-3) at Grovetown (3-3)
The Warriors, playing a region schedule for the first time, have enjoyed a 2-0 start in subregion play. Now the second-year school faces Josey for the first time.
The Eagles had their two-game winning streak snapped by Richmond Academy on Friday.
Washington-Wilkes (2-4) at Lincoln County (5-1)
This one looks like it could be lopsided, but these longtime foes played a double-overtime game last season. The Red Devils' 1960 state championship team will be honored during the game.
A.C. Flora (6-1) at Midland Valley (4-3)
The Mustangs moved to 2-0 in Region 5-AAA on Friday with their third consecutive victory. A.C. Flora just lost its first game of the season to Airport and has never faced the Mustangs.
Staff writer Billy Byler contributed to this story.