Browne, never a winner in his three years of competition since turning 50, set the tournament record for lowest score through 54 holes. After a record-tying 64 followed by 69, he's at 15-under 198.
O'Meara, winner of the 1998 Masters and British Open, had 66 in a head-to-head duel. Playing in the same pairing, he pulled even with Browne with a birdie at the ninth hole but Browne had five birdies on the tough back nine.
Six shots off the pace at 9-under 204 are Jeff Sluman, Peter Senior, Joey Sindelar and Mark Calcavecchia.