Tseng birdied four of five holes early on the back nine, then held on for a one-stroke victory over Wie with a birdie on No. 18. She finished at 13-under 200 for three rounds.
Wie (69) gave up the lead Sunday during a shaky back nine -- the same half of the course she played in 7-under 28 during a scintillating stretch Saturday.
Mika Miyazato (64) took third at 10 under.
Tseng won for the fifth time in her career, including three majors. She won the Kraft Nabisco Championship and Women's British Open this year.
CHAMPIONS TOUR: In Incheon, South Korea, Russ Cochran won the Songdo Championship for his first Champions Tour victory, making a birdie on the first playoff hole Fred Funk in the 50-and-over circuit's first event in Asia.
The 51-year-old left-hander finished at 12-under 204 at Jack Nicklaus Golf Club Korea. He won the 1991 Western Open for his lone PGA Tour title.
EUROPEAN TOUR: In Hilversum, Netherlands, PGA champion Martin Kaymer shot a final round 4-under-par 66 to win the KLM Open by four strokes.
Kaymer, who led by one overnight, carded five birdies and only one bogey when he missed the green at the short 10th hole, to stay top of the leaderboard all day and finish with a 14-under total of 266.
Christian Nilsson and Fabrizio Zanotti both shot 69s to tie for second at 10-under.
The win was the 25-year-old Kaymer's seventh on the European Tour and his third in 2010 following victories in Abu Dhabi and August's PGA Championship at Whistling Straits.
Kaymer now plans to take a week off before starting his preparation for his European Ryder Cup debut at Celtic Manor and his confidence could not be higher.
NATIONWIDE: In Sandy, Utah, Michael Putnam won the Utah Championship for his first Nationwide Tour title, closing with 4-under-par 67 for a three-stroke victory over Jhonnatan Vegas and Bradley Iles.
Putnam finished at 18-under 266 on the Willow Creek Country Club course.
Augusta's Scott Parel shot 75 and finished tied for 59th.
NGA/HOOTERS TOUR: In Elgin, S.C., Manuel Villegas shot 5-under-par 67 to win the Woodcreek Classic, holding off Swainsboro's Will Claxton by two shots at The Members Club.
Claxton also shot 67 and finished tied for second with Michael Thompson at 18-under 270.