After two overtime periods, the Pacers (7-5-4) hit four of their five attempts in the shootout for the win.
Lander, which came in ranked No. 6 in the country, finishes at 12-2-2.
All the regulation scoring happened in the first half. After Lander scored, USC Aiken’s Noel Mais tied it up at the 36:12 mark.
The Pacers will take on fourth-seeded Young Harris in the semifinals at 7:30 p.m. on Friday at Blanchard Woods Park in Evans.