Reed, a junior, birdied two of his final three holes to close out Colombia's Daniel Zuluaga, 2 and 1. Newman, the No. 61 seed, eagled the par-4 fifth hole to turn his match around and eventually defeat the other Colombian in match play, fourth-seeded Andres Echavarria, 2 and 1.
Newman, a Jaguar senior, advances to play Max Homa at 11:10 a.m today. The winner of their match will play in the third round at 4:35 p.m.
Reed advances to play NCAA Division I medalist Scott Langley. Reed and Langley will square off in the second round at 11 a.m. today.
The winner advances to the third round at 4:25 p.m.
Langley, the low amateur at the U.S. Open at Pebble Beach, dropped a 15-foot putt on the first extra hole to beat 51-year-old Tim Jackson.
Forced to play the daunting par-5 first hole yet again, Langley knocked his pitching wedge from 115 yards onto the putting surface after Jackson missed the green from nearly the same spot. Langley, who won the NCAA individual title as a junior, then ended a long trip around dry and hot Chambers Bay by sinking his birdie putt.
Langley was one of the bigger names to get through the first day of match play.
Defending champion Byeong-Hun An rolled to a 3 and 2 victory over David Dannelly in his first match, while Pac-10 co-player of the year Eugene Wong needed 19 holes to beat Joe Saladino. Wong rallied to win the final four holes of the match after being 3 down with just three to play.
Others weren't as fortunate. Local favorite and Hogan Award winner Nick Taylor -- who played nearby at Washington -- lost to Chian Kim 4 and 2.
Kevin Tway, the son of Champions Tour player Bob Tway and the 2005 U.S. Junior Amateur champ, was defeated 1-up by Blayne Barber.