Freshman Breanna Stewart added 14 points and Stefanie Dolson had 12 points and nine rebounds for the Huskies (31-4), who are seeking their sixth consecutive Final Four and eighth national championship.
Tiffany Clarke scored 16 for No. 8 seed Vandy (21-12), which lost three of its last six games.
The Huskies led by 13 at halftime and opened the second half on a 17-0 run to put the game out of reach.
MARYLAND 74, MICHIGAN STATE 49
In College Park, Md., Alyssa Thomas scored 28 points and Maryland advanced to the round of 16 for a second year in a row.
The fourth-seeded Terrapins (26-7) will face top seed Connecticut. Maryland reached the round of eight a year ago.
Thomas, a two-time Atlantic Coast Conference player of the year, had 18 at halftime to provide the Terrapins with an 11-point cushion. Her layup with 15 minutes left gave her 25 points and put Maryland up 46-30.
Annalise Pickrel and Becca Mills each scored 12 for No. 5 seed Michigan State (25-9).
OKLAHOMA CITY REGIONAL
TENNESSEE 68, CREIGHTON 52
In Knoxville, Tenn., Kamiko Williams scored 15 points and Tennessee pulled away in the second half to the regional semifinals.
The second-seeded Lady Vols (26-7), who improved to 52-0 in NCAA tournament games on their home floor, will play Oklahoma on Sunday.
Alexis Akin-Otiko scored 12 points for No. 10 seed Creighton (25-8), which was denied its first appearance in a regional semifinal.
OKLAHOMA 85, UCLA 72
In Columbus, Ohio, Aaryn Ellenberg scored 27 points and Joanna McFarland handled things inside with 20 points and 16 rebounds to send Oklahoma back to its home state for the regional semifinals.
Sharane Campbell added 19 points and Nicole Griffin had 10 for sixth-seeded Oklahoma.