The Fighting Irish (28-1, 16-0) went undefeated in the conference for the first time since joining in 1995-96 and became the first team to win six of seven games against Connecticut (27-3, 14-2) in more than two decades.
Two of those wins clinched league titles and two more were in NCAA semifinal games. The only loss was in the finals of the league tournament last season.
Diggins added 11 rebounds. Kayla McBride added 26 points before fouling out.
Kaleena Mosqueda-Lewis led UConn with 26 points and Kelly Faris added 21.
NO. 1 BAYLOR 90, KANSAS STATE 68
In Waco, Texas, Brittney Griner scored a Big 12 single-game record 50 points in her final regular-season game at Baylor – including her first dunk at home since she was a freshman.
Baylor (29-1, 18-0 Big 12) wrapped up its second consecutive undefeated conference title, becoming the first team to twice go through Big 12 play without a loss. The Lady Bears have won a record 46 consecutive Big 12 games, including tournament games, and have won 55 in a row at home.
Brittney Chambers had 22 points to lead K-State (14-16, 5-13).
NO. 24 SYRACUSE 68, NO. 13 LOUISVILLE 57
In Syracuse, N.Y., freshman Brittney Sykes and senior Kayla Alexander each scored 16 points and Syracuse snapped a late-season swoon
The victory snapped a three-game losing streak for Syracuse (23-6, 11-5 Big East) and gave the Orange the third seed and a double-bye for the Big East Tournament as they seek their first NCAA bid since 2008.
The Orange are seeded behind Notre Dame and Connecticut, while Louisville (23-7, 11-5) dropped to the fourth spot and fell to 1-4 against ranked teams, also losing to Kentucky, UConn and Notre Dame.
Louisville will also get a double-bye in the conference tournament.
Syracuse, coming off its first defeat at home this season, a 77-75 triple-overtime loss to Villanova Saturday, finished 13-1 in the Carrier Dome.
Senior Carmen Tyson-Thomas had 10 points and 12 rebounds and senior Elashier Hall added 10 points and six steals.